-
br APPBP contains a tetratricopeptide repeat
2020-08-12
APPBP2 contains a tetratricopeptide repeat (TPR) structural motif that frequently mediates protein-protein interactions [28,29], so the binding of APPBP2 with PPM1D is potentially mediated by the TPR structural motif. Since APPBP2 (PAT1) phosphorylates Mei2 and Ste11 in the controls of sex differe
-
Cell apoptosis rate br To further evaluate the rates
2020-08-12
3.3. Cell apoptosis rate To further evaluate the rates of apoptosis induced by Se-β-Lg in breast cancer cells, the cells were detected by Annexin V-FITC/PI staining. As shown in Fig.1D, E, with an increase in Se-β-Lg concentration, the proportion of apoptotic cells (Annexin VFITC＋/PI＋) increas
-
br An enzyme linked immunosorbent assay ELISA br
2020-08-12
2.4. An enzyme-linked immunosorbent assay (ELISA) Splenocytes from mice were seeded in flat-bottom 24-well plates (106 cells/well) in the presence of a plate-bound anti-CD3 antibody, and the supernatant was collected after 48 h. The supernatant concentra-tions of IFN-γ, TNF-α, IL-4, IL-13, an
-
br course Medians of all bins are connected to
2020-08-12
course. Medians of all 10 bins are connected to indicate the shape of signaling relationships (black lines), with the relationship strength quantified by signed-BP-R2, as shown on top of each individual plot. In the plot on the far right, medians of each bin are connected over the time course to d
-
br Stein WD Bates SE
2020-08-12
11. Stein WD, Bates SE, Fojo T. Intractable cancers: the many faces of multidrug resistance and the many targets it presents for therapeutic attack. Curr Drug Targets 2004;5:333–346. 13. Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, Rosenberg SA. Tumor antigen-speci
-
br C Oneyama c Src induced
2020-08-12
C. Oneyama, c-Src-induced activation of ceramide Gly-Pro-pNA impairs membrane microdomains and promotes malignant progression by facilitating the translocation of c-Src to focal adhesions, Biochem. J. 458 (1) (2014) 81–93. [48] O. Kovbasnjuk, R. Mourtazina, B. Baibakov, T. Wang, C. Elowsky, M.A.
-
br Research in context br Evidence before this study
2020-08-07
Research in context Evidence before this study Genetic mutations in key biomarkers are known to predict out-comes and response to treatment in metastatic colorectal cancer. Concordance in these biomarkers between the primary and meta-static sites is an important factor to consider with both
-
br Screening the chemical library of NPDepo br To
2020-08-07
3.2. Screening the chemical library of NPDepo To discover inhibitors of cancer-specific metabolism, we have used the phenotypic screening system described above to assay 559 com-pounds in the chemical library of NPDepo, and obtained two candidate chemotypes; neoantimycin class of compounds (
-
br G Soria M Ofri Shahak I Haas N Yaal
2020-08-07
[56] G. Soria, M. Ofri-Shahak, I. Haas, N. Yaal-Hahoshen, L. Leider-Trejo, T. Leibovich-Rivkin, P. Weitzenfeld, T. Meshel, E. Shabtai, M. Gutman, Inflammatory mediators in breast cancer: coordinated ITF2357 (Givinostat) of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal trans
-
br Introduction br Pancreatic ductal adenocarcinoma PDAC is
2020-08-04
1. Introduction Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent form of pancreatic cancer, accounting for approximately 90% of all cases [1]. With a five-year survival rate 50% R1) in PDAC patients. Patient prognosis is generally poor [8]. Fluorescence imaging using PDAC-speci
-
br Each input was a resolution image
2020-08-03
Each input was a 299 299 Lycopene image with 3 di-mensions corresponding to red (R), green (G), and blue (B) colors digitized to a 299 299 3 tensor. The input was gradually transformed by ResNet50 through 5 stages with a total of 50 rectified linear unit activations to provide nonlinearity, whi
-
br Another characteristic of senescent cells is SASP
2020-07-30
Another characteristic of senescent Paxilline is SASP. Senescent cells usually express a persistent pro-inflammatory SASP, which affects the cellular microenvironment, leading to acceleration of aging and the initiation of age-related pathologies such as malignant cancers [43]. Many efforts have
-
br Noor de Leede a Esther
2020-07-27
Noor de Leede a,1, Esther Bastiaannet a,b,1, Lydia van der Geest c, Kathleen Egan d, Cornelis van de Velde a, Lodovico Balducci e, Bert Bonsing a, Martine Extermann e, a Department of Surgical Oncology, Leiden University Medical Center, Leiden, the Netherlands b Department of Geriatrics and
-
br Results br This analysis included respondents with a
2020-07-27
3. Results This analysis included 637 respondents with a diagnosis of breast (n = 304), prostate (n = 175), or lung (n = 158) cancer. Patient ages ranged from 65 to 97 years, 78% of patients were white, 65% were in the survivorship phase of care, and 45% had two or more comorbid con-ditions (Ta
-
Qiao Y Spitz M R Shen H et
2020-07-08
Qiao, Y., Spitz, M.R., Shen, H., et al., 2002a. Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes. Carcinogenesis 23, 295–299. Qiao, Y., Spitz, M.R., Guo, Z., et al., 2002b. Rapid assessment of repair of ultraviolet DNA damag